ical activity should be added to ones lifestyle or should be encouraged. Lastly, smoking should be discontinued and/discouraged. Antihypertensive drug therapy is however, more effective. Drug therapy should be initiated with a diuretic or a -blocker, unless these drugs are contraindicated or another class of drugs is indicated. If these drugs are ineffective, alternative classes suitable for initial therapy include Ca blockers, ACE inhibitors, angiotensin II receptor blockers, 1-adrenergic blockers, and --blockers. The nutrition strategies used to treat GKM were quite parallel. Overall, she was told to decrease her dietary intake and try to lose weight, to be placed on a low triglyceride diet, to relax and rest, and to take prescribed medication, a diuretic and an ACE inhibitors. Citations: 1.http://www.springnet.com/ce/p903a.htm2.http://www.bloodpressure.com3."Arterial Hypertension." The Merck Manual. Merck and Co. 2000.MEDICATION WORKSHEETName(s) of medications (generic and trade):(1)Losartan/Hydrochlorothiazide ; Diovan HCT(2)Gemfibrizol ; LopidDrug class:(1)ACE inhibitor(captopril)/Diuretic(2)Fibric Acid DerivativePrescribed dosage: Recommended dosage: same(1)160/12.5 mg once a day(2)600 mg 2x dayMechanism of action:(1)Renin is a proteolytic enzyme produced and stored in the kidney. Its secretion is regulated by the sympathetic nervous system activity and released when there is a reduction in renal perfusion pressure due to the afferent arterioles inside the glomerulus. Renin reacts with angiotensin I, a substrate formed in the liver, then is hydrolyzed to angiotensin II. Then angiotensin II acts on specific receptor sites which leads to the increase in total peripheral resistance, heart rate, and cardiac output. Thus, increases blood pressure. However, captopril blocks the conversion of angiotensin I to angiotensin II, by inhibiting the converting enzyme. It has the angiotensin-converting enzyme inhibitor which ...
