k many forms, it was expressed earliest by the intellectual movement called Humanism. Humanism was initiated by secular men of letters rather than by the scholar-clerics who had dominated medieval intellectual life and had developed the Scholastic philosophy. Humanism began and achieved fruition first in Italy. Its predecessors were men like Dante and Petrarch, and its chief protagonists included Gianozzo Manetti, Leonardo Bruni, Marsilio Ficino, Pico della Mirandola, Lorenzo Valla, and Coluccio Salutati. The fall of Constantinople in 1453 provided Humanism with a major boost, for many eastern scholars fled to Italy, bringing with them important books and manuscripts and a tradition of Greek scholarship.From Italy the new Humanist spirit and the Renaissance it engendered spread north to all parts of Europe, aided by the invention of printing, which allowed literacy and the availability of classical texts to grow explosively. Foremost among northern Humanists was Desiderius Erasmus, whose Praise of Folly (1509) epitomized the moral essence of Humanism in its insistence on heartfelt goodness as opposed to formalistic piety. The intellectual stimulation provided by Humanists helped spark the Reformation, from which, however, many Humanists, including Erasmus, recoiled. By the end of the 16th century the battle of Reformation and Counter-Reformation had commanded much of Europe's energy and attention, while the intellectual life was poised on the brink of the Enlightenment.It was in art that the spirit of the Renaissance achieved its sharpest formulation. Art came to be seen as a branch of knowledge, valuable in its own right and capable of providing man with images of God and his creations as well as with insights into man's position in the universe. In the hands of men like Leonardo da Vinci it was even a science, a means for exploring nature and a record of discoveries. Art was to be based on the observation of the visible world and prac...