ation in the carpal tunnel that results in median nerve entrapment. These are all autoimmune diseases, meaning that the body's immune system is abnormally attacking its own tissue. Some experts believe that CTS may actually be one of the first symptoms in a number of these diseases. CTS can also be caused by long-term hemodialysis and disease such as multiple myeloma, Waldenstrom's macroglobulinemia, and non-Hodgkin's lymphoma, which cause a build up of waxy starch like protein called Amyloid in the bone and joint tissues. Acromegaly, a disease that causes abnormally long bones, is a cause of CTS. A virus known as human parvovirus was suspected in a few cases of CTS that developed in both hands. Certain medications that effect the immune system, such as interleukin-2, which is administered to cancer patients, may cause temporary CTS. There have been some reports of CTS caused by anticlotting drugs, such as warfarin.It was reported that people with a family history of CTS have a higher risk of getting it. This indicates a genetic susceptibility exists in some people. Some researchers are particularly interested in abnormalities in certain genes that regulate myelin, a fatty substance that serves as insulation for nerve fibers. Some people may be born with abnormalities of the carpal bones. It was also reported that the fluid retention during pregnancy or hormonal changes associated with menopause could cause swelling and symptoms of CTS. (Brown, 1998)Symptoms of CTS usually progress gradually over weeks and months, and some cases years. The first symptoms may be pain in the wrist and hand or numbness and tingling of the fingers. Again, except for the 5th digit. Patients may also experience a sense of weakness and a tendency to drop things. They may lose the sense of heat and cold or feel that their hands are swollen even though there is no visible swelling. Symptoms may occur not only when the hand is being used but also when it is at r...
