DMA consumption, independent of frequency of use, but not frequency of MDMA consumption independent of total consumption. In addition t_total did not correlate with t_frequency. This data showed that regular users of MDMA exhibited lower active levels of 5-HT when compared to the drug-nave control group, and the regular users of cannabis. The experimenters concluded this to suggest 5-HT impairment in MDMA users is related to the total amount of MDMA consumed. This evidence is indicative that MDMA users have more serotonergic impairment than do non-users. Because a lot of MDMA users are also marijuana users, it was important to show that MDMA would affect 5-HT independent of cannabis use. (20) This experiment showed that impairment of 5-HT levels was unrelated to cannabis use. The evidence also showed that it is total MDMA consumption and not frequency of use that effects 5-HT levels in the brain. It doesn’t matter how frequently or infrequently the drug is employed, it is a cumulative effect of all tablets consumed. This evidence is very convincing because it concurs with the findings of other experiments demonstrating 5-HT impairment in human MDMA users. (9-12) More importantly, the evidence falls in line with the research conducted on animals on MDMA and 5-Ht levels. (6-8). This research showed that MDMA use caused serotonergic impairment in animals. There is strong evidence that the 5-HT deficits observed in earlier studies in humans were caused by subjects’ use of MDMA. The convergence of evidence on this topic is very convincing.The data is not, of course, perfect. There could be inaccuracies in the self-reported drug histories of the subjects. Inaccurate estimations of drug use by drug users do not seem unlikely. The article indicates that such inaccuracies would not affect interpretation because the inaccurate estimates would affect relations only with frequency of use, which there was shown to be no prova...
