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Schizophrenia A Cognitive Dysfunction1

tent with most current thinking in neuroscience, which maps circuits and assumes distributed parallel processing. The major disadvantage of the integrative approach is that it can quickly become quite complex and lead to multinodal models that are difficult to test in a single experiment. According to neuropsychologists, there is a system that coordinates the processing, prioritization, and expression of information. Andreasen et al. (1998) suggests that it is this system that has been disturbed in schizophrenics, therefore, making it more distributed and complex. The disturbance encompasses not just executive functions, but several forms of memory, attention, emotion, and motor activity within the brain. To express the diversity of the disturbance and to call attention to the subcotical components, Andreasen et al., referred to this as “cognitive dysmetria.” As a cognitive abnormality, dysmetria would express itself as difficulty in coordinating the processing, prioritization, retrieval, and expression of information. This type of fundamental deficit could express itself as any of the broad range of symptoms of schizophrenia: hallucinations, delusions, disorganized speech, disorganized behavior, and attentional impairment. No specific group of regions has yet emerged as the “schizophrenia circuit,” but a consensus is developing on some of the nodes that may be involved, and they are probably linked together in a cognitive network. These nodes include various subregions within the frontal cortex (orbital, dorsolateral, medial), the anterior cingulate gyrus, the thalumus, several temporal-lobe subregions, and the cerebellum. There are three nodes that Andreasen et al. (1998) elaborated on in her study: prefrontal, thalamic, and cerebellum. The prefrontal cortex has been extensively studied in schizophrenia using neuropathology. Andreasen et al. (1998) found that this particular area of the brain permits the genera...

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