ystallised and dissolved once more in sulfuric acid. Further washing, oxidation and separation procedures involve potassium permanganate, benzole, and sodium carbonate. freebase/crack cocaine. Freebase/crack is derived from cocaine hydrochloride, which has been chemically treated with ammonia or baking powder to free the potent base material from the salt. Free-base was originally produced by a dangerous four-or-five step process in which the hydrochloride salt was heated with water and a volatile liquid such as ether. Base cocaine in the form of 'crack' is safer to produce; but it is no less addictive. Crack/free-base itself is indissoluble in water, so it can't easily be injected or sniffed. Instead, it is usually smoked from pipes; burnt on a piece of tin foil; or mixed with tobacco and perhaps cannabis in a smokable joint. The euphoric rush comes within a few seconds - even faster than from intravenous cocaine hydrochloride. Initially, the user may experience a profound sense of power, mastery, cleverness and uninhibited desire. Orgasm is intensified. Extravagant hyper-sexuality and rampant promiscuity are common. The exhilaration usually starts to fade within a few minutes. Soon, the crackhead desperately craves another hit. Profound depression may occur. Descent into the abyss has begun. Effects Chronic cocaine-use causes a decrease in the production of enkephalin, one of the brain's natural opioids. This in turn causes a compensatory increase in the number of mu-receptors. The number of unoccupied mu-receptors may be associated with the craving and abstinence syndrome. After chronic exposure to cocaine, the number of post-synaptic dopamine receptors in the CNS is reduced. The amount of dopamine transporter protein is increased. Tolerance to cocaine's effects does exist over prolonged use; but the extent of this physiological adaptation is relatively modest. The cocaine-user still gets high; but in the ab...
