in different combinations and with variable severity. Diagnosis is often impossible to make in infants and small children as abnormal joints hypermobility and skin elasticity are difficult to recognize, however infants may present as floppy infants. In children, joint hypermobility and hypotonia may cause delayed motor dev., problems with walking, and mild motor disturbances and often thought clumsiness. Other characteristics can be hernias, gastrointestinal diverticula, mitral valve prolapse, rectal prolapse, and easy inversion of the upper eyelid. There are laboratory test, which may confirm, or exclude the diagnosis Classical, Vascular, Arthrochalasia, Dermatosparaxis, and Kyphoscoliosis types of EDS. For Hypermobility type EDS there is no biochemical marker and diagnosis is made on the basis of symptoms or family history. Electron microscopic examination of a biopsy can show changes in the structure of collagen fibers. It is not specific, but can used as a diagnostic tool for EDS in the absence of a biological marker. In some patients an unequivocal classification cannot be made. Coagulation tests are normal (Clarke, D., Skrocki-Czerpak, K., Neumann-Potash, L).The prognosis of EDS depends on the type. Life expectancy can be shortened with the Vascular type due to the rupture of organs and blood vessel, however life expectancy is normal with all other types of EDS. Patients with EDS can be born prematurely because of premature rupture of fetal membrane in some cases (McKissick: Smith). There is treatment/ management for EDS that could be recommended by a physician, and EDS should be approached with care. A physician may prescribe braces to stabilize problems joints, but surgical repair of joints is necessary at some time. Physical and occupational therapist are used as well to help strengthen muscles and to teach people how to properly use and preserve their joints. Ascorbic acid (vitamin-c) is used by some patients to help with th...
