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Test design for Oculopharyngeal muscular dystrophy

67891011121314 Smooth--------- Eye -++++++++++++++++++++++++++++++++++++++++++++Throat -++++++++++++++++++++++++++++++++++++++++++++Leg -+++++++++++++++++++Hip -+++++++++++++++++++Shoulder -+++++++++++++++++++TABLE 2: Expected results for the possible outcome of the lack of protein binding leading to OPMD usingaffinity chromatography experiments. The +'s represent protein binding and the -'s represent lack of proteinbinding. The number of +'s illustrate the amount of bound proteins.67891011121314Smooth++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++Eye++++++++++++++++++++++++++++++++++++++++++++++Throat++++++++++++++++++++++++++++++++++++++++++++++Leg+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++Hip+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++Shoulder+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++REFERENCES:Brais, B.; Bouchard, J.; Rochefort, D.L.; Chretien, N; Tome, F.; Lafreniere, R.; Rommens, J; Uyama,E.; Nohira, O.; Blumen, S.; Korcyn, A.D.; Heutink, P; Mathieu, J; Duranceau, A.; Codere, F.; Fardeau,M.; Rouleau, G.A. (1998) Short GCG expansions in the PABP2 gene cause oculopharyngealmuscular dystrophy. Nature Genet, 18: pp164-167.Fried, K.; Arlozorov, A.; Spria, R. (1975) Autosomal recessive oculopharyngeal muscular dystrophy. J. Med. Genet. 12: pp416-418.LaFontaine, G. (Feb 24, 1996) Quebec's common muscular dystrophy gene mutation found. Medical Post: pp20.MDA Publications (http://www.mdausa.org/publications/Quest/q5resup.html) (Feb. 1998) ResearchUpdates. Quest vol.5, number 1.Rifugo, G. et al. (1997) Survey of maximum CTG/CAG repeat lengths in human and non-humanprimates: ...

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