can be produced from butadiene by carboalkoxylation, but this process is not commercialized.The production of adipic acid through the oxidation of cyclohexane is done by reacting cyclohexane with oxygen for air in the presents of a catalyze of cobalt or manganese at a temperature of 150aC to 160aC. This reaction forms a mixture of the cyclohexanol and cyclohexanone. The products are distilled to remove the unreacted cyclohexane which is recycled. The cyclohexanol and cyclohexanone are then reacted with nitric acid and air with a copper and vanadium catalyst. In this reaction, air is the oxidation reactant that produces the adipic acid. This reaction produces almost all of the world's adipic acid. There are variations of this reactions first step producing cyclohexanone and cyclohexanol from cyclohexane. This includes the using of Boron oxide hydroxide and oxygen, or by oxygen and a catalysis to form the intermediate cyclohexyl hydroperoxide with further reaction with catalytic amounts of transition metals. The second step also can be done by reacting cyclohexanol and cyclohexanone with only air and catalytic amounts Cobalt, copper, and manganese. This non-nitric acid process has the advantages of no risk of corrosion and no NOx are produced. The disadvantage is that succinic acid and glutartic acid is formed with the adipic acid, thus making purification a problem. Phenol can be substituted for cyclohexane. This involves the hydrogenation on the phenol into cyclohexanol with elemental hydrogen and a catalysis. From the cyclohexanol, nitric acid is used to form the adipic acid.The process of production of adipic acid from benzene is commercially used, but does not account for a major amount of the total production. This reaction, starting with benzene, produces cyclohexane as an intermediate step. Then the reaction continues, as in the cyclohexane path of reaction. The change of the benzene to cyclohexane is done by simply hydrogenation ...
