arate drug molecules bind covalently to the proton pump and inhibit its acid secreting abilityMechanism Of ActionSucralfateForms a gel which has high affinity for an ulcerated site and protects that site from the acidic envirionment of the stomach MetoclopramideIncreases gastric motility to speed up digestive process which decreases reflux occurrence AntacidsWeak bases which neutralize the stomach acid and decrease refluxAntacidsTablets1)Maalox XS (Strongest)2)Tums Ex3)Mylanta4) Rolaids (Weakest)Liquids1)Riopan Plus(Strongest)2)Maalox Whip XS3)Mylanta II4)Gaviscon (Weakest)AntacidsUsed as P.R.N TreatmentNot recommended for chronic useIngridientsSodium BicarbonateCalcium CarbonateAluminum HydroxideMagnesium HydroxidH2 Receptor AntagonistsCimetidine (Tagmet)Dose = 400-600mg BID or 800mg QHSSE = Diarrhea, HA, Skin rash, dizzinessMany drug interactions due to cyp450 inhibitionPregnancy category BDosage adjustments are needed for patients with renal and hepatic dysfunction H2 Receptor AntagonistFamotidine (Pepcid)Dose = 40mg QHSSE = HA, dizziness, diarrhea, constipationVery few drug interactions have been reportedPregnancy category BNo dose adjustment needed for patients with hepatic dysfunction H2 Receptor AntagonistRanitidine (Zantac)Dose = 150mg BID or 300mg QHSSE = Fatigue, dizziness, HA, GI discomfortInteractions with Procainamide, Diazepam, and Warfarin have been reportedPregnancy category BNo dose adjustment is required for patients with hepatic dysfunction Proton Pump InhibitorsOmeprazole (Prilosec)Dose = 20mg QDSE = HA, dizziness, diarrhea, abdominal pain, nausea, vomitingOmeprazole increases the concentrations of Benzodiazepines, phenytoin, and warfarinClarithromycin and Sucralfate will decrease Omperazole concentrationsPregnancy category CDose adjustment required for patients with liver impairment but not for renal impairmentProton Pump InhibitorsLansoprazole (Prevacid)Dose = 30mg QDSE = Same as with OmeprazoleLansoprazole decrea...
