The Study of Stem Cell
ES were first cultured stably and successfully seven years ago, and from a week-old embryo, and after seven years of work, only 150 well-established lines have been successfully propagated (The Future, 2005, A6). In the United States, unfortunately, the Bush administration has restricted federal research funding to only 22 lines, many of which are now contaminated and of little use in productive research. This is partly because a feeder layer of cells has always been needed to get the ES cells to grow in culture and up until this year, mouse skin cells were used for this layer and the cells were nourished with fetal calf serum, thus possibly contaminating the ES with animal proteins or pathogens. However earlier this year, researchers were able to grow ES using human feeder layers, but there is still a problem with contamination from the media used. Another problem has emerged in that ES cannot be used directly for therapeutic use because they cause tumor development, so it will be necessary for scientists to discover how to get ES to differentiate into specialized cells before transplanting them into humans (A7). Mature, differentiate cells have been used to treat diseases, such as pancreatic insulin-producing beta cells to treat diabetes, and fetal brain cells to treat brain diseases (A8).

Although the public gets stirred up over the possibilities held out for stem cells in curing diseases, the scientific community is just as interested in pursuing them

 

Despite all the scientific and philosophical problems associated with stem cell research, it is vitally important. It could hold the key to curing many chronic and debilitating diseases which bring untold suffering, and cost the country billions a year in healthcare. Every new discovery in medicine has been fought when it first appeared, but has become accepted as people see the benefits, e.g. organ transplantation which is now an everyday occurrence. Stem cells will go the same way, and acceptance will be boosted as soon as new therapies emerge. The United States is falling behind the rest of the world because of the Bush administrationĘs restrictions on federal funding, and these need to be overturned immediately.

To get around the philosophical objections to using ES, many researchers are looking into using adult stem cells therapeutically (The Future, 2005, A12). These cells reside in most parts of the body, and are pluripotent, though not omnipotent: that is, they have a restricted number of cell types they can differentiate into. They are in situ repair cells, usually found in areas where repairs are frequently needed. Bone marrow transplants are the hallmark here, because there are many hemopoietic stem cells in bone marrow, producing a continuous supply of relatively short-lived blood cells for the body and producing bone cells and adipocytes. Reviews are mixed on just how potent adult stem cells are, with some scientists holding the view that they can only differentiate cells within a narrow subset, i.e. they are already partially differentiated, and others presenting preliminary evidence that they can be regressed to a more primitive stage, and then have higher potential to differentiate into a wider range of cells (A15). For instance, some scientists have observed the capacity of adult hemopoietic stem cells to repair heart tissue damaged by heart attacks, but others claim that there is no evidence that the stem cells actually have any ef

 
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    A7 Mature | South Africa | Research Foundation | American Future | A6 United | Harvard University | | United Kingdom | European Union | stem cell | stem cell research | San Francisco | stem cells | cell research | future 2005 | therapeutic cloning | adult stem | adult stem cells | allows stem | allows stem cell | research therapeutic | research therapeutic cloning | cells treat | cells es | cell research therapeutic |  
   
 
 
 
   
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